The US First Lady Melania Trump is set to arrive in Ghana’s capital, Accra, on an unaccompanied trip that will see her visit four African countries.
The tour will focus on promoting health care and education programmes run by US foreign aid organization USAID.
She will also visit Kenya, Malawi, and Egypt to promote diplomatic relations.
In February, a row broke out after President Donald Trump allegedly used the word “shithole” to describe African nations.
Mrs. Trump’s trip to the continent is seen as helping to heal some of the divisions.
She will also promote her Be Best initiative which aims to tackle issues such as cyberbullying and boost healthy living. She tweeted that the campaign was going “international”.
Mrs. Trump said ahead of her trip that she was looking forward to visiting “four beautiful and very different countries in Africa”.
“She is interested in Africa because she has never been there before and knows that each country will have its own unique history and culture.” Stephanie Grisham, her communications director, said.
Ahead of his wife’s trip to Africa, President Trump told reporters: “We both love Africa. Africa is so beautiful. The most beautiful part of the world, in many ways.”
This view is at odds with comments he allegedly made in a private discussion in February,
Mr. Trump was accused of racism after he was reported to have used the word “shithole” to refer to African nations when talking about immigration policy.
The African Union asked him to apologize over the comment.
He later told reporters: “I am not a racist. I’m the least racist person you have ever interviewed.”
In August the president angered the South African government by falsely claiming that there was the large-scale killing of white farmers in South Africa.
The South African government reacted swiftly to counter Mr. Trump’s assertion that white South Africans were being targeted.
It is not known if Mr. Trump ever visited Africa before he became president or whether he had any business links with Africa.
President Trump has not paid much attention to the continent but has welcomed three African leaders, the presidents of Egypt, Nigeria, and Kenya, to the White House.
When Rex Tillerson, Mr. Trump’s first secretary of state, visited Africa in March he said the themes of his trip were: counterterrorism, democracy, governance, trade, and investment.
Mr. Tillerson warned Africa of China’s economic engagement with the continent which he said encouraged dependency, utilized corrupt deals and endangered its natural resources.
He also announced a $533m (£380m) humanitarian African aid plan.
On the counterterrorism front, Mr. Trump’s administration has shot up the fight against Islamist militants in the Sahel region and in Somalia.
The US has set up a drone base in Niger which is operated by the CIA.