WHO suspends hydroxychloroquine trial as COVID-19 treatment

The World Health Organization (WHO) on Monday May 25, announced that it has suspended the use of hydroxychloroquine in solidarity trial for the treatment of COVID-19.

The WHO’s director-general Tedros Adhanom Ghebreyesus said in light of a paper published last week in the Lancet that showed people taking hydroxychloroquine were at higher risk of death and heart problems than those who were not, it would pause the hydroxychloroquine arm of its solidarity global clinical trial.

Tedros said that the executive group of the so-called Solidarity Trial, in which hundreds of hospitals across several countries have enrolled patients to test several possible treatments for the novel coronavirus, had as a precaution suspended trials using that drug.

“The Executive Group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while the safety data is reviewed by the Data Safety Monitoring Board,” Tedros said.

“The other arms of the trial are continuing,” he stressed.

Hydroxychloroquine is normally used to treat arthritis but pronouncement from public figures including US President Donald Trump — who announced last week he is taking the drug — has prompted governments to bulk buy the medicine.

Brazil’s health minister also recommended last week using hydroxychloroquine, as well as the anti-malarial chloroquine, to treat even mild COVID-19 cases.

The Lancet study found that both drugs can produce potentially serious side effects, particularly heart arrhythmia.

And neither drug benefitted patients hospitalised with COVID-19, according to a Lancet study, which looked at the records of 96,000 patients across hundreds of hospitals.

Tedros stressed Monday that the two drugs “are accepted as generally safe for use in patients with autoimmune diseases or malaria.”

WHO chief scientist Soumya Swaminathan meanwhile told Monday’s briefing that the WHO-backed Solidarity Trial had been looking only at the effects of hydroxychloroquine and not chloroquine.

The decision on suspending enrolment for trials using hydroxychloroquine was “a temporary measure”, she said.

“We’re just acting by precaution,” WHO emergencies chief Michael Ryan agreed.

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